Mus musculus Gene: Cap1
Summary
InnateDB Gene IDBG-184645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cap1
Gene Name CAP, adenylate cyclase-associated protein 1 (yeast)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028656
Encoded Proteins
CAP, adenylate cyclase-associated protein 1 (yeast)
CAP, adenylate cyclase-associated protein 1 (yeast)
CAP, adenylate cyclase-associated protein 1 (yeast)
CAP, adenylate cyclase-associated protein 1 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:122859047-122886056
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000069533 ENSMUSP00000068260
ENSMUST00000106257 ENSMUSP00000101864
ENSMUST00000106255 ENSMUSP00000101862
ENSMUST00000150919
ENSMUST00000128485 ENSMUSP00000114847
ENSMUST00000140783
ENSMUST00000151041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001667 ameboidal cell migration
GO:0006898 receptor-mediated endocytosis
GO:0007010 cytoskeleton organization
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Signaling by Robo receptor pathway
Role of Abl in Robo-Slit signaling pathway
Axon guidance pathway
Developmental Biology pathway
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signaling by Robo receptor pathway
Role of Abl in Robo-Slit signaling pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Axon guidance pathway
Developmental Biology pathway
Role of Abl in Robo-Slit signaling pathway
Signaling by Robo receptor pathway
KEGG
INOH
PID BIOCARTA
How progesterone initiates the oocyte maturation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.428251 Mm.8687
RefSeq NM_007598 XM_006502695 XM_006502696 XM_006502697
OMIM
CCDS CCDS18604
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas