Version 5.4
Mus musculus Gene: Cln5
Summary
InnateDB Gene IDBG-184692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cln5
Gene Name ceroid-lipofuscinosis, neuronal 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022125
Encoded Proteins
IDBP-184694
ceroid-lipofuscinosis, neuronal 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102805:
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.[provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103070216-103077579
Strand Forward strand
Band E2.3
Transcripts
ENSMUST00000022721 ENSMUSP00000022721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005537 mannose binding
Biological Process
GO:0006465 signal peptide processing
GO:0007040 lysosome organization
GO:0007042 lysosomal lumen acidification
GO:0007420 brain development
GO:0007601 visual perception
GO:0008219 cell death
GO:0022008 neurogenesis
GO:0070085 glycosylation
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005775 vacuolar lumen
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102805
View Gene Order
ENSBTAG00000018846
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q3UMW8
TrEMBL B2RUP8
UniProt Splice Variant
Entrez Gene 211286
UniGene Mm.396789 Mm.408433
RefSeq NM_001033242
OMIM
CCDS CCDS27314
HPRD
IMGT
MGI ID MGI:2442253
MGI Symbol Cln5
EMBL AK032293 AK144635 BC025487 BC141314 BC141315 CH466544
GenPept AAH25487 AAI41315 AAI41316 BAC27797 BAE25980 EDL00493
RNA Seq Atlas 211286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca