Homo sapiens Gene: C7
Summary
InnateDB Gene IDBG-18519.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C7
Gene Name complement component 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112936
Encoded Proteins
complement component 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Complement component seven is one of five components that interact to form the cytolytic membrane attack complex (MAC)
Entrez Gene
Summary C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]
C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:40909252-40982939
Strand Forward strand
Band p13.1
Transcripts
ENST00000313164 ENSP00000322061
ENST00000508185
ENST00000489457
ENST00000486779
ENST00000513922
ENST00000494960
ENST00000464864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006883 cellular sodium ion homeostasis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0030449 regulation of complement activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
Regulation of Complement cascade pathway
Complement cascade pathway
Terminal pathway of complement pathway
KEGG
Complement and coagulation cascades pathway
Prion diseases pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
Alternative complement pathway [Biocarta view]
Classical complement pathway [Biocarta view]
Lectin induced complement pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.686730 Hs.78065
RefSeq NM_000587
HUGO
OMIM
CCDS CCDS47201
HPRD 01957
IMGT
EMBL
GenPept
RNA Seq Atlas