InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spp1

Summary

InnateDB Gene

IDBG-185485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spp1

Gene Name

secreted phosphoprotein 1

Synonyms

2AR; Apl-1; BNSP; Bsp; BSPI; Eta; ETA-1; OP; Opn; Opnl; Ric; Spp-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029304

Encoded Proteins

IDBP-185487

secreted phosphoprotein 1

IDBP-185489

secreted phosphoprotein 1

IDBP-255344

secreted phosphoprotein 1

IDBP-255346

secreted phosphoprotein 1

IDBP-255348

secreted phosphoprotein 1

IDBP-538954

secreted phosphoprotein 1

IDBP-535414

secreted phosphoprotein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21136203

Spp1 exist in secreted and intracellular form; intracellular Spp1, or iSpp1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.

InnateDB Annotation from Orthologs

Summary

PMID 21136203

[Homo sapiens] SPP1 exist in secreted and intracellular form; intracellular SPP1, or iSPP1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118785:
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:104435118-104441050

Strand

Forward strand

Band

Transcripts

ENSMUST00000086833	ENSMUSP00000084043
ENSMUST00000031243	ENSMUSP00000031243
ENSMUST00000112748	ENSMUSP00000108368
ENSMUST00000112747	ENSMUSP00000108367
ENSMUST00000112746	ENSMUSP00000108366
ENSMUST00000145084	ENSMUSP00000117338
ENSMUST00000132457	ENSMUSP00000123163

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0010033	response to organic substance
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030154	cell differentiation
GO:0030593	neutrophil chemotaxis
GO:0031214	biomineral tissue development
GO:0033280	response to vitamin D
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045780	positive regulation of bone resorption
GO:0048545	response to steroid hormone
GO:0048685	negative regulation of collateral sprouting of intact axon in response to injury

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031988	membrane-bounded vesicle
GO:0042995	cell projection
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome