Version 5.4
Mus musculus Gene: Slc29a1
Summary
InnateDB Gene IDBG-185538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc29a1
Gene Name solute carrier family 29 (nucleoside transporters), member 1
Synonyms 1200014D21Rik; AA407560; ENT1
Species Mus musculus
Ensembl Gene ENSMUSG00000023942
Encoded Proteins
IDBP-185540
solute carrier family 29 (nucleoside transporters), member 1
IDBP-185542
solute carrier family 29 (nucleoside transporters), member 1
IDBP-185544
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623455
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623460
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623468
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623470
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623473
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623474
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623478
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623483
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623484
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623485
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623487
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623488
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623489
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623491
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623492
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623493
solute carrier family 29 (nucleoside transporters), member 1
IDBP-623494
solute carrier family 29 (nucleoside transporters), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112759:
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45585200-45599606
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000051574 ENSMUSP00000063096
ENSMUST00000064889 ENSMUSP00000063757
ENSMUST00000097317 ENSMUSP00000094923
ENSMUST00000163492 ENSMUSP00000129242
ENSMUST00000171847 ENSMUSP00000126703
ENSMUST00000167692 ENSMUSP00000131976
ENSMUST00000166119 ENSMUSP00000128763
ENSMUST00000164769 ENSMUSP00000131116
ENSMUST00000171978
ENSMUST00000171081 ENSMUSP00000131217
ENSMUST00000164217 ENSMUSP00000131646
ENSMUST00000171876
ENSMUST00000167748
ENSMUST00000167863
ENSMUST00000170425
ENSMUST00000166633 ENSMUSP00000131075
ENSMUST00000164618 ENSMUSP00000126934
ENSMUST00000163905 ENSMUSP00000129240
ENSMUST00000169729 ENSMUSP00000127343
ENSMUST00000167195 ENSMUSP00000133162
ENSMUST00000172301 ENSMUSP00000129345
ENSMUST00000167332 ENSMUSP00000131483
ENSMUST00000170488 ENSMUSP00000128999
ENSMUST00000170113 ENSMUSP00000128304
ENSMUST00000168274 ENSMUSP00000127754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005337 nucleoside transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0007595 lactation
GO:0015858 nucleoside transport
GO:0015862 uridine transport
GO:0030431 sleep
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071333 cellular response to glucose stimulus
GO:0071456 cellular response to hypoxia
GO:1901642 nucleoside transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112759
View Gene Order
ENSBTAG00000015131
Not yet available
Pathways
NETPATH
REACTOME
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_232951
Transport of vitamins, nucleosides, and related molecules pathway
REACT_247934
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1206
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9JIM1
TrEMBL E9PVH9 E9PWD6 E9PWY7 E9PXM6 E9PXQ6 E9PZV0 E9Q0Q5 E9Q221 E9Q3D1 E9Q503 E9Q5E9 E9Q7R8 Q3TCZ2
UniProt Splice Variant
Entrez Gene 63959
UniGene Mm.29744
RefSeq NM_001199113 NM_001199114 NM_001199115 NM_001199116 NM_022880 XM_006524768 XM_006524769 XM_006524770 XM_006524771 XM_006524773
OMIM
CCDS CCDS28813 CCDS57096
HPRD
IMGT
MGI ID MGI:1927073
MGI Symbol Slc29a1
EMBL AC163677 AF131212 AF218255 AF305501 AK004756 AK050089 AK149483 AK170463 BC004828 BC006812 CH466559
GenPept AAF64035 AAF64036 AAF78452 AAG22828 AAH04828 AAH06812 BAB23537 BAC34063 BAE28909 BAE41813 EDL23451 EDL23452 EDL23454 EDL23456
RNA Seq Atlas 63959

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca