Version 5.4
Mus musculus Gene: Gcm1
Summary
InnateDB Gene IDBG-186151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gcm1
Gene Name glial cells missing homolog 1 (Drosophila)
Synonyms Gcm-rs2; Gcm1-rs1; GCMa; glide
Species Mus musculus
Ensembl Gene ENSMUSG00000023333
Encoded Proteins
IDBP-186153
glial cells missing homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137270:
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:78051958-78065624
Strand Forward strand
Band E1
Transcripts
ENSMUST00000024104 ENSMUSP00000024104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060018 astrocyte fate commitment
GO:0060143 positive regulation of syncytium formation by plasma membrane fusion
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060706 cell differentiation involved in embryonic placenta development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137270
View Gene Order
ENSBTAG00000008148
Not yet available
Cross-References
SwissProt P70348
TrEMBL Q3UQD1
UniProt Splice Variant
Entrez Gene 14531
UniGene Mm.1400
RefSeq NM_008103
OMIM
CCDS CCDS23356
HPRD
IMGT
MGI ID MGI:108045
MGI Symbol Gcm1
EMBL AK142574 BC066866 CH466522 D88612 U59876
GenPept AAC52822 AAH66866 BAA13650 BAE25111 EDL26359
RNA Seq Atlas 14531

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca