InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tph1

Summary

InnateDB Gene

IDBG-186197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tph1

Gene Name

tryptophan hydroxylase 1

Synonyms

Tph

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040046

Encoded Proteins

IDBP-186199

tryptophan hydroxylase 1

IDBP-266165

tryptophan hydroxylase 1

IDBP-624180

tryptophan hydroxylase 1

IDBP-624181

tryptophan hydroxylase 1

IDBP-624183

tryptophan hydroxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23243271

Tph1-deficient mice lack non-neuronal serotonin, and show impairment in neutrophil recruitment to sites of acute inflammation.

Entrez Gene

Summary

This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two tryptophan hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while tryptophan hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:46647130-46672537

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049298	ENSMUSP00000037752
ENSMUST00000110264
ENSMUST00000107669	ENSMUSP00000103296
ENSMUST00000172386	ENSMUSP00000128727
ENSMUST00000170251	ENSMUSP00000132489
ENSMUST00000170045
ENSMUST00000163468
ENSMUST00000168335	ENSMUSP00000128107

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0030279	negative regulation of ossification
GO:0035902	response to immobilization stress
GO:0042427	serotonin biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046849	bone remodeling
GO:0055114	oxidation-reduction process
GO:0060749	mammary gland alveolus development

Cellular Component

GO:0043005

neuron projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000129167

View Gene Order

ENSBTAG00000005343

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_232845

Metabolism of amino acids and derivatives pathway

REACT_218437

Serotonin and melatonin biosynthesis pathway

REACT_215158

Amine-derived hormones pathway

KEGG

mmu00380

Tryptophan metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15439

Serotonin and melatonin biosynthesis pathway

REACT_15513

Amine-derived hormones pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.248684

RefSeq

NM_001136084 NM_001276372 NM_009414 XM_006540787

OMIM

CCDS

CCDS21280 CCDS71970

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas