Version 5.4
Mus musculus Gene: Gnai3
Summary
InnateDB Gene IDBG-186305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnai3
Gene Name guanine nucleotide binding protein (G protein), alpha inhibiting 3
Synonyms AI158965; AW537698; Galphai3; Gnai-3
Species Mus musculus
Ensembl Gene ENSMUSG00000000001
Encoded Proteins
IDBP-186307
guanine nucleotide binding protein (G protein), alpha inhibiting 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21209316
Gnai3 is a G protein involved in anti-autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (Ccdc88a) and GDI inhibitor (Gpsm1). During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signalling pathways.
InnateDB Annotation from Orthologs
Summary
PMID 21209316
[Homo sapiens] GNAI3 is a G protein involved in autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (CCDC88A) and GDI inhibitor (GPSM1). During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065135:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:108107280-108146146
Strand Reverse strand
Band F2.3
Transcripts
ENSMUST00000000001 ENSMUSP00000000001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019904 protein domain specific binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G-protein coupled serotonin receptor binding
GO:0032794 GTPase activating protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006906 vesicle fusion
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030496 midbody
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0042588 zymogen granule
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000065135
View Gene Order
ENSBTAG00000013016
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_222824
Adenylate cyclase inhibitory pathway pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_207065
Activation of GABAB receptors pathway
REACT_217338
Inhibition of adenylate cyclase pathway pathway
REACT_205726
G-protein activation pathway
REACT_232481
ADP signalling through P2Y purinoceptor 12 pathway
REACT_217868
GABA B receptor activation pathway
REACT_258013
G alpha (z) signalling events pathway
REACT_224131
GABA receptor activation pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_259290
Neuronal System pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_253342
PLC beta mediated events pathway
REACT_251507
Signal amplification pathway
REACT_248370
G-protein mediated events pathway
KEGG
mmu04530
Tight junction pathway
mmu04360
Axon guidance pathway
mmu04916
Melanogenesis pathway
mmu04540
Gap junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04730
Long-term depression pathway
mmu05012
Parkinson's disease pathway
mmu04062
Chemokine signaling pathway pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04971
Gastric acid secretion pathway
mmu05145
Toxoplasmosis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_20653
ADP signalling through P2Y purinoceptor 12 pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15333
Adenylate cyclase inhibitory pathway pathway
REACT_15426
PLC beta mediated events pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_25031
GABA B receptor activation pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_25199
GABA receptor activation pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_25282
Inhibition of adenylate cyclase pathway pathway
REACT_20524
Signal amplification pathway
REACT_604
Hemostasis pathway
KEGG
hsa04540
Gap junction pathway
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04730
Long-term depression pathway
hsa04916
Melanogenesis pathway
hsa05012
Parkinson's disease pathway
hsa04062
Chemokine signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04971
Gastric acid secretion pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05145
Toxoplasmosis pathway
INOH
PID NCI
shp2_pathway
SHP2 signaling
cxcr3pathway
CXCR3-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.271703 Mm.391725 Mm.469993
RefSeq NM_010306 XM_006501007
OMIM
CCDS CCDS17751
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca