Version 5.4
Mus musculus Gene: Cdc7
Summary
InnateDB Gene IDBG-186454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc7
Gene Name cell division cycle 7 (S. cerevisiae)
Synonyms AI597260; Cdc7l1; muCdc7
Species Mus musculus
Ensembl Gene ENSMUSG00000029283
Encoded Proteins
IDBP-186458
cell division cycle 7 (S. cerevisiae)
IDBP-186460
cell division cycle 7 (S. cerevisiae)
IDBP-400467
cell division cycle 7 (S. cerevisiae)
IDBP-400466
cell division cycle 7 (S. cerevisiae)
IDBP-534332
cell division cycle 7 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000097046:
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:106964322-106984432
Strand Forward strand
Band E5
Transcripts
ENSMUST00000031221 ENSMUSP00000031221
ENSMUST00000076467 ENSMUSP00000075792
ENSMUST00000117196 ENSMUSP00000112392
ENSMUST00000118261 ENSMUSP00000113385
ENSMUST00000140378
ENSMUST00000129938 ENSMUSP00000119612
ENSMUST00000123546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0008284 positive regulation of cell proliferation
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0044770 cell cycle phase transition
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000097046
View Gene Order
ENSBTAG00000016307
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_232628
DNA Replication pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_245528
M/G1 Transition pathway
REACT_235397
G2/M Checkpoints pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_235483
DNA Replication Pre-Initiation pathway
KEGG
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_383
DNA Replication pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20842
RefSeq NM_001271566 NM_001271567 NM_001271568 NM_009863
OMIM
CCDS CCDS19498 CCDS71628 CCDS71629
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca