InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map2k4

Summary

InnateDB Gene

IDBG-186472.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k4

Gene Name

mitogen-activated protein kinase kinase 4

Synonyms

JNKK1; MEK4; MKK4; PRKMK4; Sek1; Serk1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033352

Encoded Proteins

IDBP-186474

mitogen-activated protein kinase kinase 4

IDBP-717072

IDBP-718290

IDBP-534396

mitogen-activated protein kinase kinase 4

IDBP-717202

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 10715136

[Homo sapiens] Activates JNK proteins

PMID 11343802

[Homo sapiens] Activated by MAP3K 2,3,4,5 (MEKK 2,3,4,5)

PMID 9841871

[Homo sapiens] Activated by MAP3K 2,3,4,5 (MEKK 2,3,4,5)

PMID 8940179

[Homo sapiens] Activated by MAP3K 2,3,4,5 (MEKK 2,3,4,5)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065559:
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:65688243-65788297

Strand

Reverse strand

Band

Transcripts

ENSMUST00000046963	ENSMUSP00000041282
ENSMUST00000125598	ENSMUSP00000137656
ENSMUST00000140740
ENSMUST00000140301	ENSMUSP00000137955
ENSMUST00000152096	ENSMUSP00000114219
ENSMUST00000130009	ENSMUSP00000137819
ENSMUST00000138093

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008545	JUN kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045740	positive regulation of DNA replication
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0071260	cellular response to mechanical stimulus
GO:0072709	cellular response to sorbitol