Version 5.4
Mus musculus Gene: Polr1c
Summary
InnateDB Gene IDBG-186564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr1c
Gene Name polymerase (RNA) I polypeptide C
Synonyms 40kDa; AA409007; AA959927; AL024089; Polr1e; RPA40; Rpo1-1
Species Mus musculus
Ensembl Gene ENSMUSG00000067148
Encoded Proteins
IDBP-186566
polymerase (RNA) I polypeptide C
IDBP-538890
polymerase (RNA) I polypeptide C
IDBP-538182
polymerase (RNA) I polypeptide C
IDBP-623991
polymerase (RNA) I polypeptide C
IDBP-623992
polymerase (RNA) I polypeptide C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171453:
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46243920-46248054
Strand Reverse strand
Band C
Transcripts
ENSMUST00000087026 ENSMUSP00000084252
ENSMUST00000124655 ENSMUSP00000122026
ENSMUST00000152583
ENSMUST00000142706 ENSMUSP00000116998
ENSMUST00000124126
ENSMUST00000173349 ENSMUSP00000133861
ENSMUST00000173232 ENSMUSP00000133597
ENSMUST00000174392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006383 transcription from RNA polymerase III promoter
GO:0008150 biological_process
Cellular Component
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005736 DNA-directed RNA polymerase I complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171453
View Gene Order
ENSBTAG00000018969
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_200794
Mus musculus biological processes pathway
REACT_200667
NoRC negatively regulates rRNA expression pathway
REACT_233104
RNA Polymerase III Transcription Initiation pathway
REACT_250309
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_214440
NoRC negatively regulates rRNA expression pathway
REACT_230745
Immune System pathway
REACT_251592
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_233572
Gene Expression pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_221403
RNA Polymerase III Transcription Termination pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_237241
RNA Polymerase III Transcription pathway
REACT_240508
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
REACT_205207
RNA Polymerase III Chain Elongation pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03020
RNA polymerase pathway
mmu00230
Purine metabolism pathway
mmu04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_756
RNA Polymerase III Chain Elongation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_6802
Innate Immune System pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_6900
Immune System pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_216178
RNA Polymerase III Transcription pathway
REACT_206651
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_221445
RNA Polymerase I Transcription Termination pathway
REACT_220514
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_220974
Cytosolic sensors of pathogen-associated DNA pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_217354
RNA Polymerase I Promoter Escape pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_226022
Gene Expression pathway
REACT_213138
Immune System pathway
REACT_225163
RNA Polymerase I Chain Elongation pathway
REACT_212144
RNA Polymerase III Transcription Initiation pathway
REACT_209748
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_216714
Innate Immune System pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
REACT_203737
RNA Polymerase III Chain Elongation pathway
REACT_221998
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_224876
RNA Polymerase III Transcription Termination pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z3D6
UniProt Splice Variant
Entrez Gene 20016
UniGene Mm.3458
RefSeq NM_009085
OMIM
CCDS CCDS37632
HPRD
IMGT
MGI ID MGI:103288
MGI Symbol Polr1c
EMBL AC116739
GenPept
RNA Seq Atlas 20016

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca