Version 5.4
Mus musculus Gene: Nr2c1
Summary
InnateDB Gene IDBG-186603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr2c1
Gene Name nuclear receptor subfamily 2, group C, member 1
Synonyms 4831444H07Rik; 80.3; Eenr; TR2; Tr2-11
Species Mus musculus
Ensembl Gene ENSMUSG00000005897
Encoded Proteins
IDBP-186605
nuclear receptor subfamily 2, group C, member 1
IDBP-186607
nuclear receptor subfamily 2, group C, member 1
IDBP-271194
nuclear receptor subfamily 2, group C, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120798:
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:94148023-94197211
Strand Forward strand
Band C2
Transcripts
ENSMUST00000092213 ENSMUSP00000089858
ENSMUST00000099343 ENSMUSP00000096945
ENSMUST00000105290 ENSMUSP00000100927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043401 steroid hormone mediated signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048386 positive regulation of retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120798
View Gene Order
ENSBTAG00000017729
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q505F1
TrEMBL
UniProt Splice Variant
Entrez Gene 22025
UniGene Mm.107483 Mm.472116
RefSeq NM_011629 XM_006513591 XM_006513592
OMIM
CCDS CCDS24131
HPRD
IMGT
MGI ID MGI:1352465
MGI Symbol Nr2c1
EMBL AC127596 AC138026 AK146891 AK149374 BC090662 BC094580 L26957 U28265 U28269 U28270 U28271 U28272 U28273 U28274 U28275 U28276 U28277 U28278 U28279 U28280 U30482 Y11436
GenPept AAC29502 AAC52787 AAC53253 AAH90662 AAH94580 AAL31315 BAE27509 BAE28842 CAA72244
RNA Seq Atlas 22025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca