Version 5.4
Mus musculus Gene: Krt2
Summary
InnateDB Gene IDBG-186946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt2
Gene Name keratin 2
Synonyms BB005427; Krt2-17; Krt2-2; Krt2e
Species Mus musculus
Ensembl Gene ENSMUSG00000064201
Encoded Proteins
IDBP-186948
keratin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172867:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101810689-101818169
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000023712 ENSMUSP00000023712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0005198 structural molecule activity
Biological Process
GO:0008150 biological_process
GO:0031424 keratinization
GO:0032980 keratinocyte activation
GO:0043616 keratinocyte proliferation
GO:0051546 keratinocyte migration
Cellular Component
GO:0005575 cellular_component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0045095 keratin filament
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172867
View Gene Order
ENSBTAG00000039261
Not yet available
Cross-References
SwissProt Q3TTY5
TrEMBL
UniProt Splice Variant
Entrez Gene 16681
UniGene Mm.358616
RefSeq NM_010668 XM_006520516
OMIM
CCDS CCDS37220
HPRD
IMGT
MGI ID MGI:96699
MGI Symbol Krt2
EMBL AK132476 AK161078 AK161098 BC120485 X74784
GenPept AAI20486 BAE21186 BAE36187 BAE36194 CAA52788
RNA Seq Atlas 16681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca