Version 5.4
Mus musculus Gene: Krt1
Summary
InnateDB Gene IDBG-187040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt1
Gene Name keratin 1
Synonyms Krt-2.1; Krt2-1; Krt86
Species Mus musculus
Ensembl Gene ENSMUSG00000046834
Encoded Proteins
IDBP-187042
keratin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167768:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101845428-101850786
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000023790 ENSMUSP00000023790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0001895 retina homeostasis
GO:0050728 negative regulation of inflammatory response
GO:0061436 establishment of skin barrier
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167768
View Gene Order
ENSBTAG00000046089
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt P04104
TrEMBL
UniProt Splice Variant
Entrez Gene 16678
UniGene
RefSeq NM_008473
OMIM
CCDS CCDS37221
HPRD
IMGT
MGI ID MGI:96698
MGI Symbol Krt1
EMBL AK019521 BC117842 BC117843 M10937
GenPept AAD05191 AAI17843 AAI17844 BAB31776
RNA Seq Atlas 16678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca