InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tsg101

Summary

InnateDB Gene

IDBG-187081.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsg101

Gene Name

tumor susceptibility gene 101

Synonyms

AI255943; CC2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000014402

Encoded Proteins

IDBP-187083

tumor susceptibility gene 101

IDBP-532360

tumor susceptibility gene 101

IDBP-542509

tumor susceptibility gene 101

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074319:
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:46888949-46919969

Strand

Reverse strand

Band

Transcripts

ENSMUST00000014546	ENSMUSP00000014546
ENSMUST00000146130
ENSMUST00000156335	ENSMUSP00000120856
ENSMUST00000140693
ENSMUST00000143413	ENSMUSP00000121314

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	127 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006464	cellular protein modification process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0015031	protein transport
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046755	non-lytic virus budding
GO:0051301	cell division

Cellular Component

GO:0000813	ESCRT I complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome