Mus musculus Gene: Cdca8
Summary
InnateDB Gene IDBG-187104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdca8
Gene Name cell division cycle associated 8
Synonyms 4831429J16Rik; AU044747; BOR; Borealin; D4Ertd421e; DasraB; MESRGP;
Species Mus musculus
Ensembl Gene ENSMUSG00000028873
Encoded Proteins
cell division cycle associated 8
cell division cycle associated 8
cell division cycle associated 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134690:
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:124918465-124939311
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000084296 ENSMUSP00000081319
ENSMUST00000030690 ENSMUSP00000030690
ENSMUST00000135571
ENSMUST00000125801
ENSMUST00000147074
ENSMUST00000165281 ENSMUSP00000132145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000089 mitotic metaphase
GO:0007067 mitotic nuclear division
GO:0051276 chromosome organization
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0010369 chromocenter
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:0043234 protein complex
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Separation of Sister Chromatids pathway
Resolution of Sister Chromatid Cohesion pathway
Cell Cycle pathway
M Phase pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Mitotic Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TSLP pathway
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Aurora B signaling
Cross-References
SwissProt Q8BHX3
TrEMBL E9Q2C7
UniProt Splice Variant
Entrez Gene 52276
UniGene Mm.28038
RefSeq NM_026560
OMIM
CCDS CCDS18631
HPRD
IMGT
MGI ID MGI:1196274
MGI Symbol Cdca8
EMBL AK003755 AK010905 AK020070 AK076065 AK076422 AK077717 AK077920 AK078404 AK082800 AL606933 AY550907 BC068181
GenPept AAH68181 AAT34966 BAB22980 BAB27258 BAB31983 BAC36158 BAC36334 BAC36977 BAC37063 BAC37258 BAC38627 CAM16105 CAM16106
RNA Seq Atlas 52276