InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myh1

Summary

InnateDB Gene

IDBG-187408.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh1

Gene Name

myosin, heavy polypeptide 1, skeletal muscle, adult

Synonyms

A530084A17Rik; IId; IId/x; MdMs; MHC-2X/D; MHC2X/D; MyHC-IId/x; MYHC-IIX; MyHC-IIx/d; Myhs-f; Myhs-f2; Myhsf2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056328

Encoded Proteins

IDBP-187410

myosin, heavy polypeptide 1, skeletal muscle, adult

IDBP-187412

myosin, heavy polypeptide 1, skeletal muscle, adult

IDBP-541945

myosin, heavy polypeptide 1, skeletal muscle, adult

IDBP-533017

myosin, heavy polypeptide 1, skeletal muscle, adult

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109061:
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67200052-67224575

Strand

Forward strand

Band

Transcripts

ENSMUST00000018637	ENSMUSP00000018637
ENSMUST00000075734	ENSMUSP00000075147
ENSMUST00000124516	ENSMUSP00000117569
ENSMUST00000129018	ENSMUSP00000115583

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0051015	actin filament binding

Biological Process

GO:0006936	muscle contraction
GO:0008152	metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005859	muscle myosin complex
GO:0005925	focal adhesion
GO:0014704	intercalated disc
GO:0016459	myosin complex
GO:0031672	A band
GO:0032982	myosin filament
GO:0036464	cytoplasmic ribonucleoprotein granule

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000109061

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04530

Tight junction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04530

Tight junction pathway

INOH

PID NCI

Cross-References

SwissProt

Q5SX40

TrEMBL

Q1WNQ6 Q3TT35 Q9WUS6

UniProt Splice Variant

Entrez Gene

17879

UniGene

Mm.477065

RefSeq

NM_030679

OMIM

CCDS

CCDS24855

HPRD

IMGT

MGI ID

MGI:1339711

MGI Symbol

Myh1

EMBL

AJ002522 AK161607 AL596129 AY963800 BC108329 DQ021871 DQ021872 DQ021873

GenPept

AAI08330 AAY42746 AAY42752 AAY42753 AAY42754 BAE36490 CAB40360 CAI24987

RNA Seq Atlas

17879