Version 5.4
Mus musculus Gene: Lum
Summary
InnateDB Gene IDBG-187527.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lum
Gene Name lumican
Synonyms Ldc; SLRR2D
Species Mus musculus
Ensembl Gene ENSMUSG00000036446
Encoded Proteins
IDBP-187529
lumican
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23358433
Lum facilitates early innate immune responses and orchestrates bacterial clearance and inflammation resolution in the cornea.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139329:
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:97565501-97572703
Strand Forward strand
Band C3
Transcripts
ENSMUST00000038160 ENSMUSP00000040877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0007601 visual perception
GO:0014070 response to organic cyclic compound
GO:0030199 collagen fibril organization
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051216 cartilage development
GO:0070848 response to growth factor
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005583 fibrillar collagen trimer
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139329
View Gene Order
ENSBTAG00000001745
Not yet available
Pathways
NETPATH
REACTOME
REACT_222247
Glycosaminoglycan metabolism pathway
REACT_198578
Keratan sulfate biosynthesis pathway
REACT_189085
Disease pathway
REACT_198960
Keratan sulfate degradation pathway
REACT_211754
MPS IV - Morquio syndrome B pathway
REACT_225132
MPS IV - Morquio syndrome A pathway
REACT_218935
MPS IIIC - Sanfilippo syndrome C pathway
REACT_188937
Metabolism pathway
REACT_224474
MPS I - Hurler syndrome pathway
REACT_206066
Extracellular matrix organization pathway
REACT_227993
MPS IIID - Sanfilippo syndrome D pathway
REACT_269282
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_270278
Diseases of glycosylation pathway
REACT_268957
Defective CHSY1 causes TPBS pathway
REACT_268952
Defective B3GAT3 causes JDSSDHD pathway
REACT_215504
MPS II - Hunter syndrome pathway
REACT_269263
Diseases associated with glycosaminoglycan metabolism pathway
REACT_219946
MPS IX - Natowicz syndrome pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_203949
Glycogen storage diseases pathway
REACT_208416
MPS VII - Sly syndrome pathway
REACT_271176
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_269050
Defective CHST3 causes SEDCJD pathway
REACT_215179
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_268667
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_198580
Keratan sulfate/keratin metabolism pathway
REACT_221180
MPS IIIB - Sanfilippo syndrome B pathway
REACT_221189
MPS IIIA - Sanfilippo syndrome A pathway
REACT_270086
Defective PAPSS2 causes SEMD-PA pathway
REACT_271374
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_217438
Mucopolysaccharidoses pathway
REACT_269577
Defective CHST6 causes MCDC1 pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
REACT_270174
Defective EXT2 causes exostoses 2 pathway
REACT_269276
Defective SLC26A2 causes chondrodysplasias pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_121313
Keratan sulfate degradation pathway
REACT_121120
Keratan sulfate biosynthesis pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_118779
Extracellular matrix organization pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_121288
Keratan sulfate/keratin metabolism pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_163906
ECM proteoglycans pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
REACT_269304
Defective EXT2 causes exostoses 2 pathway
REACT_269658
Defective CHST6 causes MCDC1 pathway
REACT_216637
MPS IIIA - Sanfilippo syndrome A pathway
REACT_271434
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_268431
Defective PAPSS2 causes SEMD-PA pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_205556
Glycosaminoglycan metabolism pathway
REACT_270533
Defective CHSY1 causes TPBS pathway
REACT_204212
MPS I - Hurler syndrome pathway
REACT_217291
Keratan sulfate degradation pathway
REACT_224609
MPS IIID - Sanfilippo syndrome D pathway
REACT_268552
Diseases associated with glycosaminoglycan metabolism pathway
REACT_223425
Extracellular matrix organization pathway
REACT_226837
MPS IX - Natowicz syndrome pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_208504
MPS II - Hunter syndrome pathway
REACT_220414
MPS VII - Sly syndrome pathway
REACT_268766
Defective B3GAT3 causes JDSSDHD pathway
REACT_208051
Mucopolysaccharidoses pathway
REACT_268446
Diseases of glycosylation pathway
REACT_271537
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_207047
Integrin cell surface interactions pathway
REACT_220816
MPS IIIC - Sanfilippo syndrome C pathway
REACT_211129
Glycogen storage diseases pathway
REACT_212403
MPS IIIB - Sanfilippo syndrome B pathway
REACT_270161
Defective CHST3 causes SEDCJD pathway
REACT_219139
Metabolism pathway
REACT_211440
Keratan sulfate biosynthesis pathway
REACT_269058
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_269825
Defective SLC26A2 causes chondrodysplasias pathway
REACT_270962
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_218915
MPS IV - Morquio syndrome A pathway
REACT_217121
MPS IV - Morquio syndrome B pathway
REACT_215576
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_207087
Disease pathway
REACT_210040
Keratan sulfate/keratin metabolism pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt P51885
TrEMBL
UniProt Splice Variant
Entrez Gene 17022
UniGene Mm.18888 Mm.393350
RefSeq NM_008524
OMIM
CCDS CCDS24142
HPRD
IMGT
MGI ID MGI:109347
MGI Symbol Lum
EMBL AF013262 AK014312 AK075737 AK164774 BC005550 S79461
GenPept AAB35361 AAB87767 AAH05550 BAB29264 BAC35919 BAE37912
RNA Seq Atlas 17022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca