Version 5.4
Mus musculus Gene: Csf3r
Summary
InnateDB Gene IDBG-187638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csf3r
Gene Name colony stimulating factor 3 receptor (granulocyte)
Synonyms Cd114; Csfgr; G-CSF-R; G-CSFR
Species Mus musculus
Ensembl Gene ENSMUSG00000028859
Encoded Proteins
IDBP-187640
colony stimulating factor 3 receptor (granulocyte)
IDBP-269346
colony stimulating factor 3 receptor (granulocyte)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119535:
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:126024550-126044440
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000030673 ENSMUSP00000030673
ENSMUST00000106162 ENSMUSP00000101768
ENSMUST00000153968
ENSMUST00000140426
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0019221 cytokine-mediated signaling pathway
GO:0030593 neutrophil chemotaxis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0097186 amelogenesis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119535
View Gene Order
ENSBTAG00000013334
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt P40223
TrEMBL
UniProt Splice Variant
Entrez Gene 12986
UniGene Mm.490121
RefSeq NM_001252651 NM_007782 XM_006502708 XM_006502709 XM_006502710 XM_006502711 XM_006502712 XM_006502713 XM_006502714 XM_006502716 XM_006502717 XM_006502718 XM_006502719
OMIM
CCDS CCDS18640
HPRD
IMGT
MGI ID MGI:1339755
MGI Symbol Csf3r
EMBL AL627101 M58288
GenPept AAA37673 CAM15033
RNA Seq Atlas 12986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca