InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Farp1

Summary

InnateDB Gene

IDBG-187664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Farp1

Gene Name

FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025555

Encoded Proteins

IDBP-187668

FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)

IDBP-541156

FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152767:
This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:121035200-121283744

Strand

Forward strand

Band

Transcripts

ENSMUST00000026635	ENSMUSP00000026635
ENSMUST00000135010	ENSMUSP00000116985
ENSMUST00000153607
ENSMUST00000137971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0008092	cytoskeletal protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0007416	synapse assembly
GO:0010923	negative regulation of phosphatase activity
GO:0032314	regulation of Rac GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0048813	dendrite morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030425	dendrite
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043197	dendritic spine
GO:0045202	synapse

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000152767

View Gene Order

ENSBTAG00000000146

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.223980 Mm.490290

RefSeq

NM_134082 XM_006518914 XM_006518917

OMIM

CCDS

CCDS37015

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas