InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc15a1

Summary

InnateDB Gene

IDBG-187925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc15a1

Gene Name

solute carrier family 15 (oligopeptide transporter), member 1

Synonyms

D630032F02; PECT1; PEPT1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025557

Encoded Proteins

IDBP-187927

solute carrier family 15 (oligopeptide transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088386:
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:121459621-121505254

Strand

Reverse strand

Band

Transcripts

ENSMUST00000088386

ENSMUSP00000085728

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0015198	oligopeptide transporter activity
GO:0015293	symporter activity

Biological Process

GO:0006810	transport
GO:0006857	oligopeptide transport
GO:0015031	protein transport
GO:0035672	oligopeptide transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000088386

View Gene Order

ENSBTAG00000004440

Not yet available

Pathways

NETPATH

REACTOME

REACT_247550

SLC-mediated transmembrane transport pathway

REACT_251788

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_246374

Proton/oligonucleotide cotransporters pathway

KEGG

mmu04974

Protein digestion and absorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19328

Proton/oligonucleotide cotransporters pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.155618 Mm.403973

RefSeq

NM_053079

OMIM

CCDS

CCDS37017

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas