InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tpi1

Summary

InnateDB Gene

IDBG-187986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpi1

Gene Name

triosephosphate isomerase 1

Synonyms

AI255506; Tpi; Tpi-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023456

Encoded Proteins

IDBP-536368

triosephosphate isomerase 1

IDBP-625309

triosephosphate isomerase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111669:
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:124810586-124814296

Strand

Reverse strand

Band

Transcripts

ENSMUST00000133251
ENSMUST00000149610	ENSMUSP00000125292
ENSMUST00000139716
ENSMUST00000154883
ENSMUST00000172132	ENSMUSP00000130858

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004807	triose-phosphate isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity

Biological Process

GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006098	pentose-phosphate shunt
GO:0007275	multicellular organismal development
GO:0008152	metabolic process
GO:0019682	glyceraldehyde-3-phosphate metabolic process