InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: En1

Summary

InnateDB Gene

IDBG-188157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

En1

Gene Name

engrailed 1

Synonyms

En-1; Mo-en.1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058665

Encoded Proteins

IDBP-188159

engrailed 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163064:
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the \'engrailed\' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:120602418-120607992

Strand

Forward strand

Band

E2.3

Transcripts

ENSMUST00000079721

ENSMUSP00000078659

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030182	neuron differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0030917	midbrain-hindbrain boundary development
GO:0035115	embryonic forelimb morphogenesis
GO:0035264	multicellular organism growth
GO:0042220	response to cocaine
GO:0043473	pigmentation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048666	neuron development
GO:0060173	limb development

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163064

View Gene Order

ENSBTAG00000021494

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2657

RefSeq

NM_010133

OMIM

CCDS

CCDS15235

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas