Version 5.4
Mus musculus Gene: Ubr2
Summary
InnateDB Gene IDBG-188567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubr2
Gene Name ubiquitin protein ligase E3 component n-recognin 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000023977
Encoded Proteins
IDBP-254037
ubiquitin protein ligase E3 component n-recognin 2
IDBP-254039
ubiquitin protein ligase E3 component n-recognin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000024048:
This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46928292-47010532
Strand Reverse strand
Band C
Transcripts
ENSMUST00000113337 ENSMUSP00000108963
ENSMUST00000113335 ENSMUSP00000108961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0070728 leucine binding
Biological Process
GO:0006342 chromatin silencing
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0030163 protein catabolic process
GO:0032007 negative regulation of TOR signaling
GO:0033522 histone H2A ubiquitination
GO:0071233 cellular response to leucine
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000024048
View Gene Order
ENSBTAG00000005967
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6WKZ8
TrEMBL Q3UPU3
UniProt Splice Variant
Entrez Gene 224826
UniGene Mm.28234 Mm.397834 Mm.404788
RefSeq NM_001177374 XM_006524145 XM_006524146 NM_146078
OMIM
CCDS CCDS50127 CCDS28845
HPRD
IMGT
MGI ID MGI:1861099
MGI Symbol Ubr2
EMBL AK083320 AK122254 AK143202 AY061885 AY280958 BC025617 BC026391 BC031403 BC075642
GenPept AAH25617 AAH26391 AAH31403 AAH75642 AAL32102 AAQ17202 BAC38864 BAC65536 BAE25301
RNA Seq Atlas 224826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca