Homo sapiens Gene: PPARG
Summary
InnateDB Gene IDBG-18954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPARG
Gene Name peroxisome proliferator-activated receptor gamma
Synonyms CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma;
Species Homo sapiens
Ensembl Gene ENSG00000132170
Encoded Proteins
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
peroxisome proliferator-activated receptor gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PPARG functions as an antimicrobial factor by maintaining constitutive epithelial expression of a subset of beta-defensin in the colon.
PPARG negatively regulates IFNB production in TLR3/4-stimulated macrophages by preventing IRF3 binding to the IFN-beta promoter.
MIR130A reduces hepatitis B virus (HBV) replication by down-regulating the expression of two major metabolic regulators PPARGC1A and PPARG, both of which can potently stimulate HBV replication.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Pparg negatively regulates Ifnb production in Tlr3/4 stimulated macrophages by preventing Irf3 binding to the Ifnb promoter.
[Mus musculus] The loss of PPARĪ³ in T cells increased colitis disease activity and colonic inflammatory lesions following Clostridium difficile infection.
Entrez Gene
Summary This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:12287368-12434356
Strand Forward strand
Band p25.2
Transcripts
ENST00000309576 ENSP00000312472
ENST00000287820 ENSP00000287820
ENST00000397029 ENSP00000380224
ENST00000397026 ENSP00000380221
ENST00000397023 ENSP00000380218
ENST00000397015 ENSP00000380210
ENST00000397012 ENSP00000380207
ENST00000397010 ENSP00000380205
ENST00000397000 ENSP00000380196
ENST00000396999 ENSP00000380195
ENST00000455517 ENSP00000411931
ENST00000438682 ENSP00000392285
ENST00000497594
ENST00000477039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 149 [view]
Protein-Protein 131 [view]
Protein-DNA 17 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001012 RNA polymerase II regulatory region DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004955 prostaglandin receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0033613 activating transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046965 retinoid X receptor binding
GO:0050544 arachidonic acid binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0002674 negative regulation of acute inflammatory response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006629 lipid metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0007584 response to nutrient
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009612 response to mechanical stimulus
GO:0010033 response to organic substance
GO:0010467 gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010871 negative regulation of receptor biosynthetic process
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0014070 response to organic cyclic compound
GO:0015909 long-chain fatty acid transport
GO:0019216 regulation of lipid metabolic process
GO:0019395 fatty acid oxidation
GO:0030224 monocyte differentiation
GO:0030308 negative regulation of cell growth
GO:0030522 intracellular receptor signaling pathway
GO:0030855 epithelial cell differentiation
GO:0031000 response to caffeine
GO:0031100 organ regeneration
GO:0032526 response to retinoic acid
GO:0032869 cellular response to insulin stimulus
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0033993 response to lipid
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035902 response to immobilization stress
GO:0036270 response to diuretic
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0042953 lipoprotein transport
GO:0043065 positive regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045713 low-density lipoprotein particle receptor biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046321 positive regulation of fatty acid oxidation
GO:0048469 cell maturation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050872 white fat cell differentiation
GO:0050873 brown fat cell differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051974 negative regulation of telomerase activity
GO:0055088 lipid homeostasis
GO:0055098 response to low-density lipoprotein particle stimulus
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060694 regulation of cholesterol transporter activity
GO:0060850 regulation of transcription involved in cell fate commitment
GO:0071285 cellular response to lithium ion
GO:0071300 cellular response to retinoic acid
GO:0071306 cellular response to vitamin E
GO:0071379 cellular response to prostaglandin stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071455 cellular response to hyperoxia
GO:1901558 response to metformin
GO:2000230 negative regulation of pancreatic stellate cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
PPAR signaling pathway pathway
Osteoclast differentiation pathway
Huntington's disease pathway
Pathways in cancer pathway
Thyroid cancer pathway
INOH
PID BIOCARTA
Visceral fat deposits and the metabolic syndrome [Biocarta view]
Role of ppar-gamma coactivators in obesity and thermogenesis [Biocarta view]
Basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression [Biocarta view]
PID NCI
Regulation of retinoblastoma protein
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL E7EU07 E7EUD1 E9PFJ1 Q6L9M1
UniProt Splice Variant
Entrez Gene 5468
UniGene Hs.162646
RefSeq NM_005037 NM_015869 NM_138711 NM_138712 XM_006713208
HUGO HGNC:9236
OMIM 601487
CCDS CCDS2609 CCDS2610
HPRD 03288
IMGT
EMBL AB097931 AB107271 AC090947 AC091492 AC093174
GenPept BAD20647 BAD34540
RNA Seq Atlas 5468