Mus musculus Gene: Me1
Summary
InnateDB Gene IDBG-189593.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Me1
Gene Name malic enzyme 1, NADP(+)-dependent, cytosolic
Synonyms D9Ertd267e; Mdh-1; Mod-1; Mod1;
Species Mus musculus
Ensembl Gene ENSMUSG00000032418
Encoded Proteins
malic enzyme 1, NADP(+)-dependent, cytosolic
malic enzyme 1, NADP(+)-dependent, cytosolic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065833:
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:86581371-86695953
Strand Reverse strand
Band E3.1
Transcripts
ENSMUST00000034989 ENSMUSP00000034989
ENSMUST00000185374 ENSMUSP00000140887
ENSMUST00000189968
ENSMUST00000189847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004470 malic enzyme activity
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0005515 protein binding
GO:0008948 oxaloacetate decarboxylase activity
GO:0030145 manganese ion binding
GO:0051287 NAD binding
Biological Process
GO:0006108 malate metabolic process
GO:0009725 response to hormone
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
PPARA activates gene expression pathway
KEGG
Pyruvate metabolism pathway
PPAR signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Pyruvate metabolism pathway
PPAR signaling pathway pathway
INOH
Glycolysis Gluconeogenesis pathway
Pyruvate metabolism pathway
PID BIOCARTA
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
PID NCI
Cross-References
SwissProt P06801
TrEMBL Q3TQP6 Q3TQW1
UniProt Splice Variant
Entrez Gene 17436
UniGene Mm.148155 Mm.409239 Mm.426355
RefSeq NM_001198933 NM_008615
OMIM
CCDS CCDS23383
HPRD
IMGT
MGI ID MGI:97043
MGI Symbol Me1
EMBL AK004980 AK077968 AK163278 AK163403 J02652 M26756
GenPept AAA39489 AAA39727 BAB23716 BAC37086 BAE37271 BAE37336
RNA Seq Atlas 17436