InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aurkb

Summary

InnateDB Gene

IDBG-189620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aurkb

Gene Name

aurora kinase B

Synonyms

Aik2; AIM-1; Aim1; AIRK2; AL022959; Ark2; AurB; IPL1; STK-1; Stk12; Stk5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020897

Encoded Proteins

IDBP-189622

aurora kinase B

IDBP-264052

aurora kinase B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178999:
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69045647-69051664

Strand

Forward strand

Band

Transcripts

ENSMUST00000021277	ENSMUSP00000021277
ENSMUST00000108666	ENSMUSP00000104306
ENSMUST00000139457
ENSMUST00000126576
ENSMUST00000139594
ENSMUST00000156373
ENSMUST00000149018
ENSMUST00000140531

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035174	histone serine kinase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002903	negative regulation of B cell apoptotic process
GO:0006468	protein phosphorylation
GO:0007568	aging
GO:0008283	cell proliferation
GO:0009838	abscission
GO:0031565	cytokinesis checkpoint
GO:0031577	spindle checkpoint
GO:0032091	negative regulation of protein binding
GO:0032466	negative regulation of cytokinesis
GO:0032467	positive regulation of cytokinesis
GO:0034501	protein localization to kinetochore
GO:0034644	cellular response to UV
GO:0036089	cleavage furrow formation
GO:0043146	spindle stabilization
GO:0043988	histone H3-S28 phosphorylation
GO:0051256	spindle midzone assembly involved in mitosis

Cellular Component

GO:0000776	kinetochore
GO:0000779	condensed chromosome, centromeric region
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0010369	chromocenter
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0045171	intercellular bridge
GO:0097431	mitotic spindle pole