Mus musculus Gene: Cd27
Summary
InnateDB Gene IDBG-189750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd27
Gene Name CD27 antigen
Synonyms S152; Tnfrsf7; Tp55;
Species Mus musculus
Ensembl Gene ENSMUSG00000030336
Encoded Proteins
CD27 antigen
CD27 antigen
CD27 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CD27 is a member of the tumour necrosis factor receptor superfamily that activates NF-kappaB and MAPK9 (stress-activated protein kinase/c-Jun N-terminal kinase) via TRAF2, TRAF5 and MAP3K14 (NIK).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139193:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:125232622-125237010
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000032486 ENSMUSP00000032486
ENSMUST00000112282 ENSMUSP00000107901
ENSMUST00000112281 ENSMUSP00000107900
ENSMUST00000135205
ENSMUST00000151527
ENSMUST00000152650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0042100 B cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0048305 immunoglobulin secretion
GO:0070233 negative regulation of T cell apoptotic process
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D3Z7W5
UniProt Splice Variant
Entrez Gene 21940
UniGene Mm.367714
RefSeq NM_001286753 NM_001033126 NM_001042564
OMIM
CCDS CCDS71839 CCDS39639 CCDS39638
HPRD
IMGT
MGI ID MGI:88326
MGI Symbol Cd27
EMBL AC140324
GenPept
RNA Seq Atlas 21940