Version 5.4
Mus musculus Gene: P2rx2
Summary
InnateDB Gene IDBG-189841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2rx2
Gene Name purinergic receptor P2X, ligand-gated ion channel, 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029503
Encoded Proteins
IDBP-189843
purinergic receptor P2X, ligand-gated ion channel, 2
IDBP-255928
purinergic receptor P2X, ligand-gated ion channel, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187848:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:110339812-110343035
Strand Reverse strand
Band F
Transcripts
ENSMUST00000058016 ENSMUSP00000054233
ENSMUST00000112478 ENSMUSP00000108097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0003713 transcription coactivator activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0015276 ligand-gated ion channel activity
GO:0016151 nickel cation binding
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
GO:0045340 mercury ion binding
GO:0046870 cadmium ion binding
GO:0050897 cobalt ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007268 synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0007605 sensory perception of sound
GO:0009743 response to carbohydrate
GO:0010033 response to organic substance
GO:0014832 urinary bladder smooth muscle contraction
GO:0019228 neuronal action potential
GO:0030432 peristalsis
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0048266 behavioral response to pain
GO:0048741 skeletal muscle fiber development
GO:0050909 sensory perception of taste
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005622 intracellular
GO:0005639 integral component of nuclear inner membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187848
View Gene Order
ENSBTAG00000007496
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.55948
RefSeq NM_001164833 NM_001164834 NM_153400
OMIM
CCDS CCDS51607 CCDS51608
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca