InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdh3

Summary

InnateDB Gene

IDBG-189956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh3

Gene Name

cadherin 3

Synonyms

AI385538; Cadp; Cdhp; P-cadherin; Pcad

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061048

Encoded Proteins

IDBP-189958

cadherin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:106510913-106556908

Strand

Forward strand

Band

Transcripts

ENSMUST00000080797

ENSMUSP00000079613

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0001895	retina homeostasis
GO:0007156	homophilic cell adhesion
GO:0010628	positive regulation of gene expression
GO:0010838	positive regulation of keratinocyte proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0022405	hair cycle process
GO:0031424	keratinization
GO:0032773	positive regulation of monophenol monooxygenase activity
GO:0032912	negative regulation of transforming growth factor beta2 production
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0048023	positive regulation of melanin biosynthetic process
GO:0051796	negative regulation of catagen
GO:0060070	canonical Wnt signaling pathway
GO:0060901	regulation of hair cycle by canonical Wnt signaling pathway
GO:1902910	positive regulation of melanosome transport