Version 5.4
Mus musculus Gene: Tbx18
Summary
InnateDB Gene IDBG-189964.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbx18
Gene Name T-box18
Synonyms 2810012F10Rik; 2810404D13Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000032419
Encoded Proteins
IDBP-189966
T-box18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112837:
This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:87702800-87731260
Strand Reverse strand
Band E3.1
Transcripts
ENSMUST00000034991 ENSMUSP00000034991
ENSMUST00000186698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001756 somitogenesis
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003163 sinoatrial node development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007605 sensory perception of sound
GO:0009948 anterior/posterior axis specification
GO:0016331 morphogenesis of embryonic epithelium
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051145 smooth muscle cell differentiation
GO:0072189 ureter development
GO:0090103 cochlea morphogenesis
GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112837
View Gene Order
ENSBTAG00000018161
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_023814
OMIM
CCDS CCDS40718
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca