Mus musculus Gene: Dyrk4
Summary
InnateDB Gene IDBG-190359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dyrk4
Gene Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Synonyms AW049118; Dyrk4a; Dyrk4b
Species Mus musculus
Ensembl Gene ENSMUSG00000030345
Encoded Proteins
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010219:
Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development (Zhang et al., 2005 [PubMed 15607427]).[supplied by OMIM, Mar 2008]
This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:126876020-126921839
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000032495
ENSMUST00000078521 ENSMUSP00000077606
ENSMUST00000171945 ENSMUSP00000128180
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K3W4S9
UniProt Splice Variant
Entrez Gene 101320
UniGene Mm.44896
RefSeq NM_207210 XM_006505253 XM_006505254 XM_006505255 XM_006505256
OMIM
CCDS CCDS20559
HPRD
IMGT
MGI ID MGI:1330292
MGI Symbol Dyrk4
EMBL AC165085
GenPept
RNA Seq Atlas 101320