InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccnd2

Summary

InnateDB Gene

IDBG-190590.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccnd2

Gene Name

cyclin D2

Synonyms

2600016F06Rik; AI256817; BF642806; C86853; cD2; Vin-1; Vin1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000184

Encoded Proteins

IDBP-190592

cyclin D2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118971:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008]
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:127125779-127151048

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000188

ENSMUSP00000000188

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001934	positive regulation of protein phosphorylation
GO:0007049	cell cycle
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301	cell division
GO:0051726	regulation of cell cycle

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0031965	nuclear membrane