InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dpyd

Summary

InnateDB Gene

IDBG-190734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpyd

Gene Name

dihydropyrimidine dehydrogenase

Synonyms

AI315208; DPD; E330028L06Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033308

Encoded Proteins

IDBP-190736

dihydropyrimidine dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188641:
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:118562129-119432918

Strand

Forward strand

Band

Transcripts

ENSMUST00000039177	ENSMUSP00000039429
ENSMUST00000126254
ENSMUST00000150950
ENSMUST00000149101
ENSMUST00000129148

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017150	tRNA dihydrouridine synthase activity
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006145	purine nucleobase catabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006210	thymine catabolic process
GO:0006212	uracil catabolic process
GO:0006214	thymidine catabolic process
GO:0006222	UMP biosynthetic process
GO:0008033	tRNA processing
GO:0019483	beta-alanine biosynthetic process
GO:0055114	oxidation-reduction process