Version 5.4
Mus musculus Gene: Trp53
Summary
InnateDB Gene IDBG-191036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trp53
Gene Name transformation related protein 53
Synonyms bbl; bfy; bhy; p44; p53; Tp53
Species Mus musculus
Ensembl Gene ENSMUSG00000059552
Encoded Proteins
IDBP-191038
transformation related protein 53
IDBP-264068
transformation related protein 53
IDBP-264070
transformation related protein 53
IDBP-627873
transformation related protein 53
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22105999
Tpr53 serves as a host antiviral factor and enhances both the innate and adaptive immune responses to influenza A virus.
InnateDB Annotation from Orthologs
Summary
PMID 21483755
[Homo sapiens] TP53 binds to canonical and non-canonical promoter regions of the human TLR gene family and up-regulates the expression of TLRs. The activation of TP53 can directly influence the TLR-mediated induction of cytokines.
PMID 22105999
[Homo sapiens] TP53 serves as a host antiviral factor and enhances both the innate and adaptive immune responses to influenza A virus. (Demonstrated in mice)
PMID 25505178
[Homo sapiens] Coronavirus engages papain-like proteases to escape from the innate antiviral response of the host by inhibiting TP53-IRF7-IFNB1 signalling.
Entrez Gene
Summary This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it\'s believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69580359-69591873
Strand Forward strand
Band B3
Transcripts
ENSMUST00000005371 ENSMUSP00000005371
ENSMUST00000108658 ENSMUSP00000104298
ENSMUST00000108657 ENSMUSP00000104297
ENSMUST00000147512
ENSMUST00000130540
ENSMUST00000171247 ENSMUSP00000127130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 164 experimentally validated interaction(s) in this database.
They are also associated with 644 interaction(s) predicted by orthology.
Experimentally validated
Total 164 [view]
Protein-Protein 137 [view]
Protein-DNA 18 [view]
Protein-RNA 1 [view]
DNA-DNA 8 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 644 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030971 receptor tyrosine kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035033 histone deacetylase regulator activity
GO:0035035 histone acetyltransferase binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0051087 chaperone binding
GO:0051721 protein phosphatase 2A binding
GO:0097371 MDM2/MDM4 family protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000733 DNA strand renaturation
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001836 release of cytochrome c from mitochondria
GO:0002309 T cell proliferation involved in immune response
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002931 response to ischemia
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006979 response to oxidative stress
GO:0006983 ER overload response
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007275 multicellular organismal development
GO:0007369 gastrulation
GO:0007406 negative regulation of neuroblast proliferation
GO:0007417 central nervous system development
GO:0007569 cell aging
GO:0008104 protein localization
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell proliferation
GO:0008340 determination of adult lifespan
GO:0009303 rRNA transcription
GO:0009411 response to UV
GO:0009651 response to salt stress
GO:0009792 embryo development ending in birth or egg hatching
GO:0010165 response to X-ray
GO:0010332 response to gamma radiation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0021549 cerebellum development
GO:0030308 negative regulation of cell growth
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031065 positive regulation of histone deacetylation
GO:0031497 chromatin assembly
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032461 positive regulation of protein oligomerization
GO:0033077 T cell differentiation in thymus
GO:0034103 regulation of tissue remodeling
GO:0034613 cellular protein localization
GO:0034644 cellular response to UV
GO:0035264 multicellular organism growth
GO:0035690 cellular response to drug
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0042127 regulation of cell proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046677 response to antibiotic
GO:0048147 negative regulation of fibroblast proliferation
GO:0048568 embryonic organ development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051262 protein tetramerization
GO:0051276 chromosome organization
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0070243 regulation of thymocyte apoptotic process
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0070266 necroptotic process
GO:0071158 positive regulation of cell cycle arrest
GO:0071456 cellular response to hypoxia
GO:0071479 cellular response to ionizing radiation
GO:0071850 mitotic cell cycle arrest
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090343 positive regulation of cell aging
GO:0090399 replicative senescence
GO:0090403 oxidative stress-induced premature senescence
GO:0097252 oligodendrocyte apoptotic process
GO:1901525 negative regulation of macromitophagy
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005667 transcription factor complex
GO:0005669 transcription factor TFIID complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0016605 PML body
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141510
View Gene Order
ENSBTAG00000001069
Not yet available
Pathways
NETPATH
REACTOME
REACT_212633
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_224553
Hemostasis pathway
REACT_188957
Cellular responses to stress pathway
REACT_188971
Oncogene Induced Senescence pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_257943
p53-Dependent G1 DNA Damage Response pathway
REACT_254524
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_188804
Cell Cycle pathway
REACT_256790
Stabilization of p53 pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_188820
Cellular Senescence pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_246312
G1/S DNA Damage Checkpoints pathway
REACT_209428
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
KEGG
mmu05213
Endometrial cancer pathway
mmu05219
Bladder cancer pathway
mmu05217
Basal cell carcinoma pathway
mmu04115
p53 signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu05216
Thyroid cancer pathway
mmu05218
Melanoma pathway
mmu04110
Cell cycle pathway
mmu04010
MAPK signaling pathway pathway
mmu05214
Glioma pathway
mmu05222
Small cell lung cancer pathway
mmu04210
Apoptosis pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu05212
Pancreatic cancer pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu05016
Huntington's disease pathway
mmu05200
Pathways in cancer pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_346
Transcriptional activation of cell cycle inhibitor p21 pathway
REACT_20549
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_309
Stabilization of p53 pathway
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_1194
Activation of NOXA and translocation to mitochondria pathway
REACT_121
Activation of PUMA and translocation to mitochondria pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_169121
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_202
Transcriptional activation of p53 responsive genes pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_169274
Cellular Senescence pathway
REACT_299
Signaling by NOTCH pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_604
Hemostasis pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_217767
Oncogene Induced Senescence pathway
REACT_215067
Factors involved in megakaryocyte development and platelet production pathway
REACT_218643
Stabilization of p53 pathway
REACT_219415
G1/S DNA Damage Checkpoints pathway
REACT_206069
Cellular responses to stress pathway
REACT_212196
Hemostasis pathway
REACT_214934
Cell Cycle pathway
REACT_215025
Cellular Senescence pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_224434
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_227679
p53-Dependent G1 DNA Damage Response pathway
REACT_211071
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_204623
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_214732
DNA Damage/Telomere Stress Induced Senescence pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05216
Thyroid cancer pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa05217
Basal cell carcinoma pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04115
p53 signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05016
Huntington's disease pathway
hsa05200
Pathways in cancer pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
plk3_pathway
PLK3 signaling events
aurora_a_pathway
Aurora A signaling
p53downstreampathway
Direct p53 effectors
myc_activpathway
Validated targets of C-MYC transcriptional activation
lkb1_pathway
LKB1 signaling events
p53regulationpathway
p53 pathway
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
p75ntrpathway
p75(NTR)-mediated signaling
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
bard1pathway
BARD1 signaling events
Cross-References
SwissProt
TrEMBL A5JTV6 A6YM30 Q3UGQ1 Q549C9 Q6TDG9 Q8C526 Q9JLE1
UniProt Splice Variant
Entrez Gene 22059
UniGene Mm.474963 Mm.487603
RefSeq NM_011640 XM_006533157 XM_006533158 NM_001127233
OMIM
CCDS CCDS36193 CCDS48826
HPRD
IMGT
MGI ID MGI:98834
MGI Symbol Trp53
EMBL AB017815 AB017816 AB020317 AB021961 AF151353 AF161020 AF190269 AK079711 AK138777 AK147815 AL731687 AY423848 BC005448 CH466601 EF570972 EF634061 EU031806 M13872 M13873 M13874 S77930 X00741 X00876 X00877 X00878 X00879 X00880 X00881 X00882 X00883 X00884 X00885 X01237
GenPept AAA39881 AAA39882 AAA39883 AAB21108 AAD39535 AAD44340 AAF43276 AAH05448 AAR00340 ABQ44583 ABR29561 ABS81351 BAA82339 BAA82340 BAA82343 BAA82344 BAC37729 BAE23775 BAE28156 CAA25323 CAA25420 CAA25625 EDL10507
RNA Seq Atlas 22059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca