Version 5.4
Mus musculus Gene: Plscr1
Summary
InnateDB Gene IDBG-191069.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plscr1
Gene Name phospholipid scramblase 1
Synonyms MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b; Tras1; Tras2
Species Mus musculus
Ensembl Gene ENSMUSG00000032369
Encoded Proteins
IDBP-191071
phospholipid scramblase 1
IDBP-790042
phospholipid scramblase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22453241
Plscr1 regulates Tlr9 trafficking to endosomal compartment and plays an important role in the induction of type I IFN response in plasmocytoid dendritic cells.
InnateDB Annotation from Orthologs
Summary
PMID 22453241
[Homo sapiens] PLSCR1 regulates TLR9 trafficking to endosomal compartment and plays an important role in the induction of type I IFN response in plasmocytoid dendritic cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188313:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:92249750-92272278
Strand Forward strand
Band E3.3
Transcripts
ENSMUST00000093801 ENSMUSP00000091318
ENSMUST00000186364 ENSMUSP00000139479
ENSMUST00000187952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0017124 SH3 domain binding
GO:0017128 phospholipid scramblase activity
GO:0042609 CD4 receptor binding
Biological Process
GO:0006659 phosphatidylserine biosynthetic process
GO:0006953 acute-phase response
GO:0017121 phospholipid scrambling
GO:0030099 myeloid cell differentiation
GO:0032091 negative regulation of protein binding
GO:0033003 regulation of mast cell activation
GO:0035455 response to interferon-alpha
GO:0043065 positive regulation of apoptotic process
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070782 phosphatidylserine exposure on apoptotic cell surface
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:0097193 intrinsic apoptotic signaling pathway
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0031012 extracellular matrix
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188313
View Gene Order
ENSBTAG00000022227
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q3UDV5 Q4FK16
UniProt Splice Variant
Entrez Gene 22038
UniGene
RefSeq XM_006511052 NM_011636
OMIM
CCDS CCDS52886
HPRD
IMGT
MGI ID MGI:893575
MGI Symbol Plscr1
EMBL AF159593 AK003628 AK149903 CT010236 D78354 D78355
GenPept AAF77076 BAA23663 BAA23664 BAB22897 BAE29156 CAJ18444
RNA Seq Atlas 22038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca