InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trpc1

Summary

InnateDB Gene

IDBG-191539.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpc1

Gene Name

transient receptor potential cation channel, subfamily C, member 1

Synonyms

Mtrp1; Trp1; Trrp1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032839

Encoded Proteins

IDBP-191541

transient receptor potential cation channel, subfamily C, member 1

IDBP-789768

transient receptor potential cation channel, subfamily C, member 1

IDBP-789770

transient receptor potential cation channel, subfamily C, member 1

IDBP-789771

transient receptor potential cation channel, subfamily C, member 1

IDBP-789772

transient receptor potential cation channel, subfamily C, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144935:
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:95705082-95750375

Strand

Reverse strand

Band

E3.3

Transcripts

ENSMUST00000053785	ENSMUSP00000057640
ENSMUST00000189137	ENSMUSP00000139672
ENSMUST00000190604	ENSMUSP00000139577
ENSMUST00000190497	ENSMUSP00000140550
ENSMUST00000188141
ENSMUST00000186235	ENSMUSP00000140994
ENSMUST00000190205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0044325	ion channel binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0046541	saliva secretion
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051480	cytosolic calcium ion homeostasis
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030017	sarcomere
GO:0043034	costamere
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft