InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Elk4

Summary

InnateDB Gene

IDBG-191654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elk4

Gene Name

ELK4, member of ETS oncogene family

Synonyms

2310011G17Rik; A130026I01Rik; BB162516; SAP-1; Sap1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026436

Encoded Proteins

IDBP-191656

ELK4, member of ETS oncogene family

IDBP-191658

ELK4, member of ETS oncogene family

IDBP-531721

ELK4, member of ETS oncogene family

IDBP-541553

ELK4, member of ETS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158711:
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:132007607-132032612

Strand

Forward strand

Band

Transcripts

ENSMUST00000027696	ENSMUSP00000027696
ENSMUST00000086556	ENSMUSP00000083743
ENSMUST00000146188
ENSMUST00000124579
ENSMUST00000146432	ENSMUSP00000118880
ENSMUST00000147218	ENSMUSP00000114255
ENSMUST00000131159

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0070932	histone H3 deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000158711

View Gene Order

ENSBTAG00000004953

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

INOH website

FGF8 signaling (Mouse) pathway

INOH website

FGF signaling pathway pathway

INOH website

PDGF signaling pathway pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

NetPath_5

ID pathway

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

INOH website

PDGF signaling pathway pathway

PID NCI

p38alphabetadownstreampathway

Signaling mediated by p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

F6WN08 Q8C6Q0

UniProt Splice Variant

Entrez Gene

13714

UniGene

Mm.254233 Mm.483050 Mm.488735

RefSeq

NM_007923 XM_006529126 XM_006529127 XM_006529128 XM_006529129 XM_006529130

OMIM

CCDS

CCDS35704

HPRD

IMGT

MGI ID

MGI:102853

MGI Symbol

Elk4

EMBL

AC107837 AK054075

GenPept

BAC35647

RNA Seq Atlas

13714