Version 5.4
Mus musculus Gene: Aldh1a3
Summary
InnateDB Gene IDBG-191846.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aldh1a3
Gene Name aldehyde dehydrogenase family 1, subfamily A3
Synonyms ALDH6; RALDH3; V1
Species Mus musculus
Ensembl Gene ENSMUSG00000015134
Encoded Proteins
IDBP-191848
aldehyde dehydrogenase family 1, subfamily A3
IDBP-626626
aldehyde dehydrogenase family 1, subfamily A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184254:
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq, Jul 2008]
This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:66390892-66427517
Strand Reverse strand
Band C
Transcripts
ENSMUST00000015278 ENSMUSP00000015278
ENSMUST00000173756
ENSMUST00000174701 ENSMUSP00000133370
ENSMUST00000174209
ENSMUST00000174215
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0070324 thyroid hormone binding
GO:0070403 NAD+ binding
Biological Process
GO:0002072 optic cup morphogenesis involved in camera-type eye development
GO:0002138 retinoic acid biosynthetic process
GO:0007626 locomotory behavior
GO:0008152 metabolic process
GO:0021768 nucleus accumbens development
GO:0031076 embryonic camera-type eye development
GO:0042472 inner ear morphogenesis
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0043065 positive regulation of apoptotic process
GO:0048048 embryonic eye morphogenesis
GO:0048386 positive regulation of retinoic acid receptor signaling pathway
GO:0050885 neuromuscular process controlling balance
GO:0055114 oxidation-reduction process
GO:0060013 righting reflex
GO:0060166 olfactory pit development
GO:0060324 face development
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184254
View Gene Order
ENSBTAG00000009125
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00410
beta-Alanine metabolism pathway
mmu00350
Tyrosine metabolism pathway
mmu00340
Histidine metabolism pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00360
Phenylalanine metabolism pathway
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
mmu00982
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00340
Histidine metabolism pathway
hsa00360
Phenylalanine metabolism pathway
hsa00350
Tyrosine metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Phenylalanine degradation pathway
INOH website
Tyrosine metabolism pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.140988
RefSeq NM_053080
OMIM
CCDS CCDS21345
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca