Version 5.4
Mus musculus Gene: Asb7
Summary
InnateDB Gene IDBG-191879.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asb7
Gene Name ankyrin repeat and SOCS box-containing 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030509
Encoded Proteins
IDBP-191883
ankyrin repeat and SOCS box-containing 7
IDBP-539171
ankyrin repeat and SOCS box-containing 7
IDBP-541592
ankyrin repeat and SOCS box-containing 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183475:
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:66644565-66689596
Strand Reverse strand
Band C
Transcripts
ENSMUST00000068980 ENSMUSP00000070866
ENSMUST00000131320 ENSMUSP00000115921
ENSMUST00000124899 ENSMUSP00000122395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183475
View Gene Order
ENSBTAG00000010514
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q91ZU0
TrEMBL
UniProt Splice Variant
Entrez Gene 117589
UniGene Mm.34785 Mm.412719 Mm.414107 Mm.483523
RefSeq NM_080443 XM_006540567 XM_006540568
OMIM
CCDS CCDS21346
HPRD
IMGT
MGI ID MGI:2152835
MGI Symbol Asb7
EMBL AC115761 AC120791 AF398968 CH466543
GenPept AAK97490 EDL07214
RNA Seq Atlas 117589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca