Version 5.4
Mus musculus Gene: Olr1
Summary
InnateDB Gene IDBG-192019.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Olr1
Gene Name oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms LOX-1; Scare1; SR-EI
Species Mus musculus
Ensembl Gene ENSMUSG00000030162
Encoded Proteins
IDBP-192021
oxidized low density lipoprotein (lectin-like) receptor 1
IDBP-536523
oxidized low density lipoprotein (lectin-like) receptor 1
IDBP-787784
oxidized low density lipoprotein (lectin-like) receptor 1
IDBP-787785
oxidized low density lipoprotein (lectin-like) receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173391:
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer\'s disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:129485246-129507165
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000032265 ENSMUSP00000032265
ENSMUST00000162815 ENSMUSP00000124660
ENSMUST00000183258 ENSMUSP00000138228
ENSMUST00000182784 ENSMUSP00000138588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002376 immune system process
GO:0006898 receptor-mediated endocytosis
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0008219 cell death
GO:0042157 lipoprotein metabolic process
GO:0042542 response to hydrogen peroxide
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0019897 extrinsic component of plasma membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000173391
View Gene Order
ENSBTAG00000004547
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
KEGG
mmu03320
PPAR signaling pathway pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
hsa03320
PPAR signaling pathway pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.446458
RefSeq NM_138648 XM_006505304
OMIM
CCDS CCDS20588
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca