Version 5.4
Mus musculus Gene: Vac14
Summary
InnateDB Gene IDBG-192039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vac14
Gene Name Vac14 homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000010936
Encoded Proteins
IDBP-192041
Vac14 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103043:
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:110618638-110720396
Strand Forward strand
Band D3
Transcripts
ENSMUST00000034190 ENSMUSP00000034190
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019209 kinase activator activity
Biological Process
GO:0006970 response to osmotic stress
GO:0008219 cell death
GO:0042327 positive regulation of phosphorylation
GO:0043550 regulation of lipid kinase activity
Cellular Component
GO:0005774 vacuolar membrane
GO:0005783 endoplasmic reticulum
GO:0010008 endosome membrane
GO:0070772 PAS complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103043
View Gene Order
ENSBTAG00000023795
Not yet available
Pathways
NETPATH
REACTOME
REACT_198975
Synthesis of PIPs at the early endosome membrane pathway
REACT_198972
Synthesis of PIPs at the late endosome membrane pathway
REACT_198970
Synthesis of PIPs at the Golgi membrane pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_120918
Synthesis of PIPs at the late endosome membrane pathway
REACT_198975
Synthesis of PIPs at the early endosome membrane pathway
REACT_198972
Synthesis of PIPs at the late endosome membrane pathway
REACT_198970
Synthesis of PIPs at the Golgi membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_188643
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q80WQ2
TrEMBL Q8K279
UniProt Splice Variant
Entrez Gene 234729
UniGene
RefSeq NM_146216
OMIM
CCDS CCDS22663
HPRD
IMGT
MGI ID MGI:2157980
MGI Symbol Vac14
EMBL AK046826 AK171577 BC032215 BC052199
GenPept AAH32215 AAH52199 BAC32886 BAE42537
RNA Seq Atlas 234729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca