Version 5.4
Mus musculus Gene: Acap1
Summary
InnateDB Gene IDBG-192390.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acap1
Gene Name ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000001588
Encoded Proteins
IDBP-192392
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
IDBP-264145
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17005562
[Homo sapiens] ACAP1 (CENTB1) selectively down-regulates NF-kappaB activation via NODs pathways, creating a feedback loop and suggesting a novel role of ACAP1 in innate immune responses to bacteria and inflammatory responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072818:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69881567-69895539
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000001631 ENSMUSP00000001631
ENSMUST00000108622 ENSMUSP00000104262
ENSMUST00000127238
ENSMUST00000148037
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0007165 signal transduction
GO:0008150 biological_process
GO:0016042 lipid catabolic process
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
GO:0055038 recycling endosome membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000072818
View Gene Order
ENSBTAG00000010527
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_153788
OMIM
CCDS CCDS24919
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca