Homo sapiens Gene: RAF1
Summary
InnateDB Gene IDBG-19277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAF1
Gene Name v-raf-1 murine leukemia viral oncogene homolog 1
Synonyms c-Raf; CMD1NN; CRAF; NS5; Raf-1;
Species Homo sapiens
Ensembl Gene ENSG00000132155
Encoded Proteins
v-raf-1 murine leukemia viral oncogene homolog 1
v-raf-1 murine leukemia viral oncogene homolog 1
v-raf-1 murine leukemia viral oncogene homolog 1
v-raf-1 murine leukemia viral oncogene homolog 1
v-raf-1 murine leukemia viral oncogene homolog 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:12583601-12664226
Strand Reverse strand
Band p25.2
Transcripts
ENST00000251849 ENSP00000251849
ENST00000442415 ENSP00000401888
ENST00000432427 ENSP00000398591
ENST00000423275 ENSP00000401088
ENST00000416093 ENSP00000391265
ENST00000471449
ENST00000465826
ENST00000475353
ENST00000494557
ENST00000460610
ENST00000491290
ENST00000492690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 252 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 252 [view]
Protein-Protein 252 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017016 Ras GTPase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0001666 response to hypoxia
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0031333 negative regulation of protein complex assembly
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034220 ion transmembrane transport
GO:0035019 somatic stem cell maintenance
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response
GO:0045104 intermediate filament cytoskeleton organization
GO:0045595 regulation of cell differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071550 death-inducing signaling complex assembly
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000145 regulation of cell motility
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031143 pseudopodium
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
EGFR1 pathway
ID pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL5 pathway
Leptin pathway
TSH pathway
FSH pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
Rap1 signalling pathway
SHC-related events pathway
Transmembrane transport of small molecules pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
GP1b-IX-V activation signalling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Neuronal System pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
RAF activation pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Stimuli-sensing channels pathway
SHC-related events triggered by IGF1R pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
Frs2-mediated activation pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Post NMDA receptor activation events pathway
IRS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
SHC-mediated signalling pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Ion channel transport pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Insulin receptor signalling cascade pathway
Interleukin-2 signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
Transmission across Chemical Synapses pathway
SHC1 events in ERBB2 signaling pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
Signalling to RAS pathway
Signaling by PDGF pathway
MEK activation pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Disease pathway
RAF phosphorylates MEK pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Role of ├?-arrestins in the activation and targeting of map kinases [Biocarta view]
Inhibition of cellular proliferation by gleevec [Biocarta view]
Signaling pathway from g-protein families [Biocarta view]
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Bcr signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Regulation of splicing through sam68 [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Melanocyte development and pigmentation pathway [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
Ras signaling pathway [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Roles of ├? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Tpo signaling pathway [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Nongenotropic Androgen signaling
Ceramide signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Trk receptor signaling mediated by the MAPK pathway
Class I PI3K signaling events mediated by Akt
Regulation of retinoblastoma protein
IL2-mediated signaling events
Internalization of ErbB1
Downstream signaling in na´ve CD8+ T cells
ErbB1 downstream signaling
Signaling events mediated by focal adhesion kinase
IGF1 pathway
Endothelins
BCR signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Ras signaling in the CD4+ TCR pathway
ErbB2/ErbB3 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
SHP2 signaling
GMCSF-mediated signaling events
CXCR3-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
p38 signaling mediated by MAPKAP kinases
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632896
RefSeq NM_002880 XM_005265355 XM_005265360
HUGO
OMIM
CCDS CCDS2612
HPRD 01265
IMGT
EMBL
GenPept
RNA Seq Atlas