Mus musculus Gene: Aars
Summary
InnateDB Gene IDBG-192811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aars
Gene Name alanyl-tRNA synthetase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031960
Encoded Proteins
alanyl-tRNA synthetase
alanyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090861:
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41%% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:111033144-111057664
Strand Forward strand
Band E1
Transcripts
ENSMUST00000034441 ENSMUSP00000034441
ENSMUST00000125268 ENSMUSP00000122388
ENSMUST00000154546
ENSMUST00000142770
ENSMUST00000145059
ENSMUST00000124285
ENSMUST00000128320
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016597 amino acid binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
GO:0046872 metal ion binding
Biological Process
GO:0001942 hair follicle development
GO:0006400 tRNA modification
GO:0006419 alanyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
GO:0006457 protein folding
GO:0021680 cerebellar Purkinje cell layer development
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034620 cellular response to unfolded protein
GO:0043039 tRNA aminoacylation
GO:0043200 response to amino acid
GO:0043524 negative regulation of neuron apoptotic process
GO:0043588 skin development
GO:0050885 neuromuscular process controlling balance
GO:0050905 neuromuscular process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
Alanine Aspartate Asparagine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8BGQ7
TrEMBL Q6PDM7 Q8R346
UniProt Splice Variant
Entrez Gene 234734
UniGene Mm.24174 Mm.334810 Mm.415470
RefSeq NM_028274 NM_146217 XM_006530921 XM_006530922 XM_006530923 XM_006530924
OMIM
CCDS CCDS40478
HPRD
IMGT
MGI ID MGI:2384560
MGI Symbol Aars
EMBL AK044451 AK085725 BC026611 BC033273 BC058620
GenPept AAH26611 AAH33273 AAH58620 BAC31927 BAC39520
RNA Seq Atlas 234734