InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GLCE

Summary

InnateDB Gene

IDBG-19316.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLCE

Gene Name

glucuronic acid epimerase

Synonyms

HSEPI

Species

Homo sapiens

Ensembl Gene

ENSG00000138604

Encoded Proteins

IDBP-19318

glucuronic acid epimerase

IDBP-589980

glucuronic acid epimerase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM, Jun 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:69160584-69272217

Strand

Forward strand

Band

q23

Transcripts

ENST00000261858	ENSP00000261858
ENST00000559798
ENST00000559420	ENSP00000454092
ENST00000559500

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0047464	heparosan-N-sulfate-glucuronate 5-epimerase activity
GO:0050379	UDP-glucuronate 5'-epimerase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030210	heparin biosynthetic process
GO:0044281	small molecule metabolic process