Mus musculus Gene: Acadvl | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-193209.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Acadvl | ||||||||||||||||||||||
Gene Name | acyl-Coenzyme A dehydrogenase, very long chain | ||||||||||||||||||||||
Synonyms | vlcad | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000018574 | ||||||||||||||||||||||
Encoded Proteins |
acyl-Coenzyme A dehydrogenase, very long chain
acyl-Coenzyme A dehydrogenase, very long chain
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:70010183-70015411 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | B3 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Unfolded Protein Response (UPR) pathway
Metabolism pathway
Metabolism of proteins pathway
Metabolism of lipids and lipoproteins pathway
IRE1alpha activates chaperones pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
XBP1(S) activates chaperone genes pathway
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
|
||||||||||||||||||||||
KEGG |
Fatty acid degradation pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
XBP1(S) activates chaperone genes pathway
IRE1alpha activates chaperones pathway
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Unfolded Protein Response (UPR) pathway
Metabolism of lipids and lipoproteins pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Metabolism of proteins pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Metabolism pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
IRE1alpha activates chaperones pathway
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
Metabolism of proteins pathway
Metabolism of lipids and lipoproteins pathway
XBP1(S) activates chaperone genes pathway
Metabolism pathway
Unfolded Protein Response (UPR) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
|
||||||||||||||||||||||
KEGG |
Fatty acid degradation pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
FOXA2 and FOXA3 transcription factor networks
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.18630 | ||||||||||||||||||||||
RefSeq | NM_017366 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS24931 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||