Mus musculus Gene: Dlg4
Summary
InnateDB Gene IDBG-193317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlg4
Gene Name discs, large homolog 4 (Drosophila)
Synonyms Dlgh4; PSD-95; PSD95; SAP90; SAP90A;
Species Mus musculus
Ensembl Gene ENSMUSG00000020886
Encoded Proteins
discs, large homolog 4 (Drosophila)
discs, large homolog 4 (Drosophila)
discs, large homolog 4 (Drosophila)
discs, large homolog 4 (Drosophila)
discs, large homolog 4 (Drosophila)
discs, large homolog 4 (Drosophila)
discs, large homolog 4 (Drosophila)
discs, large homolog 4 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132535:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70017085-70045532
Strand Forward strand
Band B3
Transcripts
ENSMUST00000018700 ENSMUSP00000018700
ENSMUST00000108589 ENSMUSP00000104230
ENSMUST00000108588 ENSMUSP00000104229
ENSMUST00000108586
ENSMUST00000133140 ENSMUSP00000126707
ENSMUST00000124568 ENSMUSP00000121053
ENSMUST00000135916 ENSMUSP00000135994
ENSMUST00000134376 ENSMUSP00000115206
ENSMUST00000132597 ENSMUSP00000114165
ENSMUST00000143920 ENSMUSP00000136419
ENSMUST00000138004
ENSMUST00000123687 ENSMUSP00000134545
ENSMUST00000131497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 372 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Experimentally validated
Total 372 [view]
Protein-Protein 372 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 84 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0030165 PDZ domain binding
GO:0031697 beta-1 adrenergic receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031812 P2Y1 nucleotide receptor binding
GO:0032403 protein complex binding
GO:0033130 acetylcholine receptor binding
GO:0035254 glutamate receptor binding
GO:0035255 ionotropic glutamate receptor binding
GO:0042043 neurexin family protein binding
GO:0097110 scaffold protein binding
Biological Process
GO:0002091 negative regulation of receptor internalization
GO:0006461 protein complex assembly
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007626 locomotory behavior
GO:0016188 synaptic vesicle maturation
GO:0035176 social behavior
GO:0035418 protein localization to synapse
GO:0035641 locomotory exploration behavior
GO:0042220 response to cocaine
GO:0045184 establishment of protein localization
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050806 positive regulation of synaptic transmission
GO:0050885 neuromuscular process controlling balance
GO:0060997 dendritic spine morphogenesis
GO:0071625 vocalization behavior
GO:0097113 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097120 receptor localization to synapse
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000821 regulation of grooming behavior
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0008328 ionotropic glutamate receptor complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0030863 cortical cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032839 dendrite cytoplasm
GO:0043197 dendritic spine
GO:0044224 juxtaparanode region of axon
GO:0044300 cerebellar mossy fiber
GO:0044306 neuron projection terminus
GO:0044309 neuron spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Ionotropic activity of Kainate Receptors pathway
Activation of Kainate Receptors upon glutamate binding pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Activation of Ca-permeable Kainate Receptor pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Post NMDA receptor activation events pathway
Axon guidance pathway
NrCAM interactions pathway
L1CAM interactions pathway
Neuronal System pathway
Developmental Biology pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Transmission across Chemical Synapses pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Ionotropic activity of Kainate Receptors pathway
Axon guidance pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
Activation of Kainate Receptors upon glutamate binding pathway
Trafficking of AMPA receptors pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Transmission across Chemical Synapses pathway
L1CAM interactions pathway
Activation of Ca-permeable Kainate Receptor pathway
NrCAM interactions pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
CREB phosphorylation through the activation of CaMKII pathway
KEGG
Huntington's disease pathway
INOH
PID BIOCARTA
Nitric oxide signaling pathway [Biocarta view]
PID NCI
ErbB4 signaling events
Cross-References
SwissProt Q62108
TrEMBL E9PXG2 J3KMS4 J3QMR8 Q6XVF6
UniProt Splice Variant
Entrez Gene 13385
UniGene Mm.27256 Mm.489451
RefSeq XM_006532142 XM_006532145 XM_006532147 XM_006537120 XM_006537123 XM_006537125 NM_007864 NM_001109752 XM_006537126 XM_006532148 XM_006537127 XM_006537124 XM_006532149 XM_006532146
OMIM
CCDS CCDS36202 CCDS48829
HPRD
IMGT
MGI ID MGI:1277959
MGI Symbol Dlg4
EMBL AL596185 AY207048 AY207049 BC014807 D50621
GenPept AAH14807 AAQ56707 BAA09297 CAI35168 CAI35169 CAI35170
RNA Seq Atlas 13385