Version 5.4
Mus musculus Gene: Ntrk3
Summary
InnateDB Gene IDBG-193339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ntrk3
Gene Name neurotrophic tyrosine kinase, receptor, type 3
Synonyms AW125844; Ntrk3_tv3; TrkC
Species Mus musculus
Ensembl Gene ENSMUSG00000059146
Encoded Proteins
IDBP-193341
neurotrophic tyrosine kinase, receptor, type 3
IDBP-193343
neurotrophic tyrosine kinase, receptor, type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140538:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:78192362-78578408
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000039431 ENSMUSP00000037909
ENSMUST00000039438 ENSMUSP00000038324
ENSMUST00000151885
ENSMUST00000155795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046875 ephrin receptor binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001764 neuron migration
GO:0001933 negative regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019056 modulation by virus of host transcription
GO:0030335 positive regulation of cell migration
GO:0032148 activation of protein kinase B activity
GO:0032856 activation of Ras GTPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0038179 neurotrophin signaling pathway
GO:0042490 mechanoreceptor differentiation
GO:0045471 response to ethanol
GO:0046777 protein autophosphorylation
GO:0048665 neuron fate specification
GO:0048678 response to axon injury
GO:0048691 positive regulation of axon extension involved in regeneration
GO:0048712 negative regulation of astrocyte differentiation
GO:0050927 positive regulation of positive chemotaxis
GO:0051412 response to corticosterone
GO:0060548 negative regulation of cell death
GO:0070306 lens fiber cell differentiation
GO:0071300 cellular response to retinoic acid
GO:0090102 cochlea development
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000140538
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.421840 Mm.440279
RefSeq NM_008746 NM_182809
OMIM
CCDS CCDS21371 CCDS21372
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca