Homo sapiens Gene: HMGCS1
Summary
InnateDB Gene IDBG-19361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGCS1
Gene Name 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Synonyms HMGCS;
Species Homo sapiens
Ensembl Gene ENSG00000112972
Encoded Proteins
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:43289395-43313512
Strand Reverse strand
Band p12
Transcripts
ENST00000325110 ENSP00000322706
ENST00000433297 ENSP00000399402
ENST00000508319
ENST00000514610
ENST00000507004
ENST00000507293
ENST00000511774 ENSP00000427339
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0008144 drug binding
GO:0016853 isomerase activity
GO:0042803 protein homodimerization activity
GO:0043177 organic acid binding
Biological Process
GO:0001889 liver development
GO:0006629 lipid metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0007420 brain development
GO:0008152 metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0008584 male gonad development
GO:0009645 response to low light intensity stimulus
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0014074 response to purine-containing compound
GO:0033197 response to vitamin E
GO:0034698 response to gonadotropin
GO:0042493 response to drug
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046690 response to tellurium ion
GO:0055094 response to lipoprotein particle stimulus
GO:0070723 response to cholesterol
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071397 cellular response to cholesterol
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Not yet available
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Cholesterol biosynthesis pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Synthesis and degradation of ketone bodies pathway
Valine, leucine and isoleucine degradation pathway
Butanoate metabolism pathway
Terpenoid backbone biosynthesis pathway
INOH
Butanoate metabolism pathway
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
Srebp control of lipid synthesis [Biocarta view]
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt Q01581
TrEMBL A0A024R059 D6RIW1 Q8N995
UniProt Splice Variant
Entrez Gene 3157
UniGene Hs.397729 Hs.602526
RefSeq NM_002130 NM_001098272
HUGO HGNC:5007
OMIM 142940
CCDS CCDS34154
HPRD 07515
IMGT
EMBL AC114947 AK095492 AK315593 BC000297 BT007302 CH471119 L25798 X66435
GenPept AAA62411 AAH00297 AAP35966 BAC04559 BAG37965 CAA47061 EAW56054 EAW56056
RNA Seq Atlas 3157